Control of growth factor binding and release in bisphosphonate functionalized hydrogels guides rapid differentiation of precursor cells in vitro. (27th November 2015)
- Record Type:
- Journal Article
- Title:
- Control of growth factor binding and release in bisphosphonate functionalized hydrogels guides rapid differentiation of precursor cells in vitro. (27th November 2015)
- Main Title:
- Control of growth factor binding and release in bisphosphonate functionalized hydrogels guides rapid differentiation of precursor cells in vitro
- Authors:
- Kootala, Sujit
Zhang, Yu
Ghalib, Sara
Tolmachev, Vladimir
Hilborn, Jöns
Ossipov, Dmitri A. - Abstract:
- Abstract : Sequestration and active release of BMP-2 in HA-BP hydrogels to precursor cells aid rapid differentiation to osteoblasts. Abstract : An in situ cross-linkable hyaluronan hydrogel functionalized with bisphosphonate (BP) groups allows tunable release of bone morphogenetic protein-2 (BMP-2) determined by the amount of BP groups. The high affinity of matrix-anchored BP groups towards BMP-2 permits guided differentiation of entrapped progenitor cells in 3-D cultures.
- Is Part Of:
- Biomaterials science. Volume 4:Number 2(2016:Feb.)
- Journal:
- Biomaterials science
- Issue:
- Volume 4:Number 2(2016:Feb.)
- Issue Display:
- Volume 4, Issue 2 (2016)
- Year:
- 2016
- Volume:
- 4
- Issue:
- 2
- Issue Sort Value:
- 2016-0004-0002-0000
- Page Start:
- 250
- Page End:
- 254
- Publication Date:
- 2015-11-27
- Subjects:
- Biomedical materials -- Periodicals
610.28 - Journal URLs:
- http://pubs.rsc.org/en/journals/journalissues/bm ↗
http://www.rsc.org/ ↗ - DOI:
- 10.1039/c5bm00355e ↗
- Languages:
- English
- ISSNs:
- 2047-4830
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 2087.724000
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 1472.xml