Asymmetric total synthesis of Lycopodium alkaloids α-obscurine, N-desmethyl-α-obscurine, β-obscurine and N-desmethyl-β-obscurine. Issue 1 (24th November 2015)

• Record Type: Journal Article
• Authors: Fu, Jian-Guo; Xu, Guang-Qiang; Ding, Rui; Lin, Guo-Qiang; Sun, Bing-Feng
• Is Part Of: Organic chemistry frontiers. Volume 3:Issue 1(2016:Jan.)
• Page Start: 62
• Page End: 65
• Publication Date: 2015-11-24
• Subjects: Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1039/c5qo00355e
• Languages: English
• ISSNs: 2052-4110

Abstract

Abstract : We report herein the asymmetric total synthesis of α-obscurine (1 ), β-obscurine (2 ), N -desmethyl-α-obscurine (3 ), and N -desmethyl-β-obscurine (4 ). Abstract : The asymmetric total synthesis of α-obscurine (1 ), β-obscurine (2 ), N -desmethyl-α-obscurine (3 ), and N -desmethyl-β-obscurine (4 ) was accomplished. Key reactions in the construction of the A/B/C-ring system include the Buchwald–Hartwig coupling reaction, the Heck cyclization, and the diastereoselective hydrogenation.