Ca2+, pH and thermo triple-responsive mechanized Zr-based MOFs for on-command drug release in bone diseases. Issue 1 (2nd December 2015)

• Record Type: Journal Article
• Authors: Tan, Li-Li; Song, Nan; Zhang, Sean Xiao-An; Li, Haiwei; Wang, Bo; Yang, Ying-Wei
• Is Part Of: Journal of materials chemistry. Volume 4:Issue 1(2016)
• Page Start: 135
• Page End: 140
• Publication Date: 2015-12-02
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/c5tb01789k
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : A new design opens up the possibility of developing smart biomaterials for bone cancer (lowered pH and hypercalcemia) therapy. Abstract : We report a new approach towards the design of multi-stimuli responsive "gated scaffolds" based on the combination of capped metal–organic frameworks (MOFs) and supramolecular[2]pseudorotaxanes. These mechanized Zr-MOFs showed negligible premature release, high drug encapsulation, low cytotoxicity and good biocompatibility. Around or inside the bone tumour cells, the pH, lysosomal pH, and osteoclast pH are observed to be lowered (acidosis), and thus the resulting osteolysis increases the Ca 2+ concentration (hypercalcemia). The drug release from the mechanized MOFs was triggered by the simultaneous variations of pH and Ca 2+ concentration in bone tumour cells. Hyperthermia (also called thermal therapy or thermotherapy) as a popular type of cancer treatment technique can also control drug release in the above-mentioned system. This design opens up the possibility of developing smart biomaterials for bone regeneration and cancer therapy.