On the masked mycotoxin zearalenone-14-glucoside. Does the mask truly hide?. (1st March 2016)

• Record Type: Journal Article
• Authors: Dellafiora, Luca; Perotti, Alessio; Galaverna, Gianni; Buschini, Annamaria; Dall'Asta, Chiara
• Is Part Of: Toxicon. Volume 111(2016)
• Page Start: 139
• Page End: 142
• Publication Date: 2016-03-01
• Subjects: Bioconversion -- Masked mycotoxins -- Zearalenone -- Human cell lines -- Hydrolysis; Toxins -- Periodicals; Venom -- Periodicals; 615.9
• DOI: 10.1016/j.toxicon.2016.01.053
• Languages: English
• ISSNs: 0041-0101

Abstract

Abstract: In the matter of foodborne mycotoxins, beside a number of regulated compounds, regulations are totally missing for phase-II plant metabolites – the toxicological knowledge of which is still in its infancy. Currently, zearalenone-14-glucoside is in the pipeline and its toxicological role is under a glowing scientific debate. In our work it clearly showed high toxicological concerns as it is prone to conversion to well-known toxic compounds (i.e. zearalenone and both zearalenol isomers) when exposed to breast cancer cells culture. The need of future risk assessment studies has been pointed out accordingly. Graphical abstract: Highlights: ZEN-14-Glc is cleaved in breast cancer cell culture to release the parent form. Besides deglycosilation, ZEN-14-Glc biotransformation may occur in MCF7 cells as well. The xenoestrogenic activity of masked ZEN is not quenched by glucosilation.