An insulin-binding protein from the venom of a solitary wasp Eumenes pomiformis binds to apolipophorin III in lepidopteran hemolymph. (1st March 2016) - Baek, Ji Hyeong
Abstract: EpIBP, an insulin-like peptide-binding protein, is a major protein component of the venom of a solitary hunting wasp, Eumenes pomiformis . To evaluate the bioactivity, bacteria-expressed EpIBP was injected into Spodoptera exigua larvae, resulting in a higher survival rate and reduced loss of body weight under starvation conditions than control larvae. EpIBP was found to interact with apolipophorin III (apoLp III), implying that EpIBP might function by altering the apoLp III-mediated metabolism of prey. Graphical abstract: Highlights: EpIBP increased survivorship and reduced body weight loss of prey under starvation. Apolipophorin III was found to interact with IBPs. EpIBP might regulate apoLp III-mediated metabolism of prey.