Sol–gel based materials for biomedical applications. (April 2016)

• Record Type: Journal Article
• Authors: Owens, Gareth J.; Singh, Rajendra K.; Foroutan, Farzad; Alqaysi, Mustafa; Han, Cheol-Min; Mahapatra, Chinmaya; Kim, Hae-Won; Knowles, Jonathan C.
• Is Part Of: Progress in materials science. Volume 77(2016:Apr.)
• Page Start: 1
• Page End: 79
• Publication Date: 2016-04
• Subjects: AAM anodic alumina membrane -- AP 3-aminopropyl -- ASO antisense oligonucleotides -- BCP biphasic calcium phosphate -- BG bioactive glass -- BMSC bone marrow mesenchymal stem cell -- cAMP cyclic adenosine monophosphate -- CaP calcium phosphate -- CHO Chinese hamster ovary cells -- CNT carbon nanotubes -- CTAB cetyl trimethylammonium bromide -- CT computer tomography -- DDS drug delivery system -- DMHA N, N-dimethylhexadecylamine -- DNA deoxyribonucleic acid -- DOX doxorubicin -- ECM extracellular matrix -- EDC 1-ethyl-3-(3-dimethyl-aminopropyl) carbodiimide -- F127 Pluronic® F-127 -- FAP N-folate-3-aminopropyl -- FITC fluorescein isothiocyanate -- GP guanidinopropyl -- GEGP 3-[N-(2-guanidinoethyl)guanidine] propyl -- GFP green fluorescent protein -- HA hydroxyapatite -- HCA carbonated hydroxyapatite -- INDO intermediate neglect of differential overlap -- MCM mobile composition of matter -- MBG mesoporous bioactive glass -- MNP magnetic nanoparticle -- MRI magnetic resonance imaging -- MSC mesenchymal stem cell -- MSN mesoporous silica nanoparticle -- MTES methyltriethoxysilane -- MTMS trimethoxymethylsilane -- NC network connectivity -- NHS N-hydroxysuccinimide -- NIR near infrared -- NLR long rod nanoparticles -- NMR nuclear magnetic resonance -- NP nanoparticle -- NSR short rod nanoparticles -- P123 Pluronic® P-123 -- PAMAM polyamidoamine -- PAA polyacrylic acid -- PCL poly(ε-caprolactone) -- PDMAAm poly-(N, N′-dimethyl acrylamide) -- PDMS poyldimethylsiloxane -- PEG polyethylene glycol -- PEI polyethyleneimine -- PET position emission tomography -- PLL poly(l-lysine) -- PLLA poly-l-lactic acid -- PMMA poly(methyl methacrylate) -- PS polystyrene -- PVA polyvinyl alcohol -- PVP polyvinylpyrrolidone -- QD quantum dots -- RBC red blood cells -- RNA ribonucleic acid -- ROS reactive oxygen species -- SBF simulated body fluid -- siRNA small interfering RNA -- SPECT photon emission computed tomography -- SPION superparamagnetic iron oxide nanoparticles -- TEA triethanolamine -- TEM transmission electron microscopy -- TEOS tetraethoxy orthosilicate -- TMB trimethylbenzene -- TMES trimethylethoxysilane -- TMOS tetramethyl orthosilicate -- TTCP tetracalcium phosphate -- TTIP titanium tetraisopropoxide -- β-TCP β-tricalcium phosphate -- 3D three-dimensional; Sol–gel -- Biomaterials -- Biomedical -- Tissue engineering -- Drug delivery -- Nanomedicine; Materials science -- Periodicals; Science des matériaux -- Périodiques; 620.1105
• DOI: 10.1016/j.pmatsci.2015.12.001
• Languages: English
• ISSNs: 0079-6425

Abstract

Abstract: Sol–gel chemistry offers a flexible approach to obtaining a diverse range of materials. It allows differing chemistries to be achieved as well as offering the ability to produce a wide range of nano-/micro-structures. The paper commences with a generalized description of the various sol–gel methods available and how these chemistries control the bulk properties of the end products. Following this, a more detailed description of the biomedical areas where sol–gel materials have been explored and found to hold significant potential. One of the interesting fields that has been developed recently relates to hybrid materials that utilize sol–gel chemistry to achieve unusual composite properties. Another intriguing feature of sol–gels is the unusual morphologies that are achievable at the micro- and nano-scale. Subsequently the ability to control pore chemistry at a number of different length scales and geometries has proven to be a fruitful area of exploitation, that provides excellent bioactivity and attracts cellular responses as well as enables the entrapment of biologically active molecules and their controllable release for therapeutic action. The approaches of fine-tuning surface chemistry and the combination with other nanomaterials have also enabled targeting of specific cell and tissue types for drug delivery with imaging capacity.