Atrial arrhythmogenesis in obstructive sleep apnea: Therapeutic implications. (April 2016)

• Record Type: Journal Article
• Authors: Linz, Dominik; Linz, Benedikt; Hohl, Mathias; Böhm, Michael
• Is Part Of: Sleep medicine reviews. Volume 26(2016)
• Page Start: 87
• Page End: 94
• Publication Date: 2016-04
• Subjects: Atrial fibrillation -- Obstructive sleep apnea -- Continuous positive airway pressure -- Renal denervation -- Atrial electrophysiology -- Animal experiment; AERP atrial effective refractory period -- AF atrial fibrillation -- AHI apnea-hypopnea index -- CPAP continuous positive airway pressure -- CSA central sleep apnea -- NTP negative thoracic pressure -- OSA obstructive sleep apnea -- PVI pulmonary vein isolation -- RAAS renin angiotensin aldosterone system -- RDN renal denervation; Sleep disorders -- Periodicals; Sleep Disorders -- Periodicals; Sommeil, Troubles du -- Périodiques; Electronic journals; 616.8498
• DOI: 10.1016/j.smrv.2015.03.003
• Languages: English
• ISSNs: 1087-0792

Abstract

Summary: The prevalence of sleep disordered breathing like obstructive sleep apnea (OSA) among patients with atrial fibrillation (AF) is 40–50%. OSA reduces success rate of catheter based and pharmacological antiarrhythmic treatment. Additionally, efficient treatment of OSA by continuous positive airway pressure ventilation (CPAP), the first line therapy of OSA, has been shown to improve catheter ablation success rates in AF-patients. A systematic literature search using several databases was performed to review the pathophysiology of obstructive apneas in OSA potentially leading to the development of a substrate for AF and to explain potential mechanisms involved in the clinically observed atrial antiarrhythmic effect of effective CPAP therapy.