The role of HIF in immunity and inflammation. (February 2016)

• Record Type: Journal Article
• Authors: Cummins, Eoin P.; Keogh, Ciara E.; Crean, Daniel; Taylor, Cormac T.
• Is Part Of: Molecular aspects of medicine. Volume 47/48(2016)
• Page Start: 24
• Page End: 34
• Publication Date: 2016-02
• Subjects: Hypoxia -- inflammation -- leukocyte -- hypoxia inducible factor; Pathology, Molecular -- Periodicals; Medicine -- Periodicals; Biochemistry -- Periodicals; Medicine -- Periodicals; Molecular Biology -- Periodicals; Pathologie moléculaire -- Périodiques; Médecine -- Périodiques; Electronic journals; 612.015
• DOI: 10.1016/j.mam.2015.12.004
• Languages: English
• ISSNs: 0098-2997

Abstract

Abstract: Uncontrolled or non-resolving inflammation underpins a range of disease states including rheumatoid arthritis, inflammatory bowel disease and atherosclerosis. Hypoxia is a prominent feature of chronically inflamed tissues. This is due to elevated oxygen consumption by highly metabolically active inflamed resident cells and activated infiltrating immunocytes, as well as diminished oxygen supply due to vascular dysfunction. Tissue hypoxia can have a significant impact upon inflammatory signaling pathways in immune and non-immune cells and this can impact upon disease progression. In this review, we will discuss the relationship between tissue hypoxia and inflammation and identify how hypoxia-sensitive signaling pathways are potential therapeutic targets in chronic inflammatory disease.