Atypical case of Morvan's syndrome. (March 2016)

• Record Type: Journal Article
• Authors: Lotan, Itay; Djaldetti, Ruth; Hellman, Mark A.; Benninger, Felix
• Is Part Of: Journal of clinical neuroscience. Volume 25(2016:Mar.)
• Page Start: 132
• Page End: 134
• Publication Date: 2016-03
• Subjects: Guillain–Barré' syndrome -- Morvan's syndrome -- Paraneoplastic syndrome -- Peripheral neuropathy; Brain -- Surgery -- Periodicals; Neurosciences -- Periodicals; Nervous system -- Surgery -- Periodicals; Brain -- surgery -- Periodicals; Neurosurgical Procedures -- Periodicals; Neurosciences -- Periodicals; Electronic journals; 616.8
• DOI: 10.1016/j.jocn.2015.06.025
• Languages: English
• ISSNs: 0967-5868

Abstract

Highlights: We describe an atypical case of Morvan's syndrome. Initial manifestation was suggestive of Guillain–Barré syndrome. Further clinical course was more characteristic of Morvan's syndrome. Episodes of fever of unknown origin after recovery may represent relapse. Abstract: Morvan's syndrome is a rare neurological condition characterized by the combination of neuromyotonia, autonomic instability and encephalopathy, associated with auto-antibodies against voltage-gated potassium channels. We report a patient with an initial presentation suggestive of typical Guillain–Barré syndrome (GBS), who later developed clinical and laboratory features compatible with Morvan's syndrome. Several months after resolution of the neurological symptoms, as well as disappearance of the characteristic anti-leucine-rich, glioma inactivated 1 (anti-LGI1) antibodies, the patient presented with episodes of fever of unknown origin, during which the antibodies became positive again, suggesting the possibility of a relapse. In this case, both the GBS-like symptoms at presentation and the isolated episodes of fever of unknown origin during follow-up are atypical, and may suggest the presence of an additional, yet unknown antibody.