Clinoposides A–F: meroterpenoids with protective effects on H9c2 cardiomyocyte from Clinopodium chinense. Issue 9 (18th January 2016)

• Record Type: Journal Article
• Authors: Zhu, Yin-Di; Wu, Hai-Feng; Ma, Guo-Xu; Chen, Rong-Chang; Long, Hai-Lin; Zuo, Zhi-Li; Luo, Yun; Zhu, Nai-Liang; Hou, Bo; Xu, Xu-Dong; Sun, Gui-Bo; Yang, Jun-Shan
• Is Part Of: RSC advances. Volume 6:Issue 9(2016)
• Page Start: 7260
• Page End: 7266
• Publication Date: 2016-01-18
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c5ra27485k
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : Six novel flavonoid–triterpene saponin meroterpenoids, clinoposides A–F (1–6 ), with two unusual skeletons were isolated from Clinopodium chinense . Abstract : Six novel flavonoid–triterpene saponin meroterpenoids, clinoposides A–F (1–6 ), with two unusual skeletons were isolated from Clinopodium chinense . Clinoposides A–F represent a new class of isopentenyl flavonoid saponin. Their structures were determined based on spectroscopic data and chemical methods. The relative and absolute stereochemistries were assigned using a combination of NOESY and ECD. A possible biogenetic pathway for1–6 is proposed. The protective effects of clinoposides A–F against H2 O2 -induced H9c2 cardiomyocyte injury were tested, and all compounds exhibited significantly dose-dependent effects, clinoposides B, D and F showed better protective effects as evidence by increased levels of SOD, CAT and GSH-Px but reduced MDA, LDH, caspase-3 and -9 levels.