Antileukemic activity of lignans and phenylpropanoids of Cinnamomum parthenoxylon. Issue 3 (1st February 2016)

• Record Type: Journal Article
• Authors: Adfa, Morina; Rahmad, Rizki; Ninomiya, Masayuki; Yudha S., Salprima; Tanaka, Kaori; Koketsu, Mamoru
• Is Part Of: Bioorganic & medicinal chemistry letters. Volume 26:Issue 3(2016)
• Page Start: 761
• Page End: 764
• Publication Date: 2016-02-01
• Subjects: Cinnamomum parthenoxylon -- Antileukemic activity -- Lignan -- Phenylpropanoid -- Apoptosis; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1016/j.bmcl.2015.12.096
• Languages: English
• ISSNs: 0960-894X

Abstract

Graphical abstract: Abstract: In this study, we evaluated the in vitro cytotoxicity of fractions and isolated constituents from Cinnamomum parthenoxylon woods against human leukemia HL-60 and U937 cells. The n -Hex, EtOAc, and MeOH–H2 O fractions of the woods inhibited cell proliferation in both cell lines. Our phytochemical investigation of the n -Hex and EtOAc fractions led to the isolation of lignans and phenylpropanoids, whose chemical structures were confirmed by spectroscopic analyses. All isolated compounds were evaluated for their in vitro antileukemic activity; especially, hinokinin and cubebin exhibited strong inhibition toward U937 cell proliferation. Morphological observation indicated that these cytotoxic actions were mediated by apoptosis. Our findings suggested that an oxygenated functional group at the C-9 position in dibenzylfuran skeleton contributed their potency. In addition, these results enhanced the ethnopharmacological value of C . parthenoxylon .