Biocompatibility evaluation of novel β-type titanium alloy (Ti–35Nb–7Zr–5Ta)98Si2in vitro. Issue 123 (26th November 2015)

• Record Type: Journal Article
• Authors: Sun, Yu; Song, Yang; Zuo, Jianlin; Wang, Shengqun; Gao, Zhongli
• Is Part Of: RSC advances. Volume 5:Issue 123(2015)
• Page Start: 101794
• Page End: 101801
• Publication Date: 2015-11-26
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c5ra19767h
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : Cell proliferation, osteoblast adhesion, morphology, differentiation, inflammatory response, apoptosis and biomineralization were investigated to evaluate the biocompatibility of (Ti–35Nb–7Zr–5Ta)98 Si2 alloy. Abstract : Background : low elastic modulus and high strength are two critical requirements for orthopedic implant materials. A newly reported ultrafine-grained β-type titanium alloy (Ti–35Nb–7Zr–5Ta)98 Si2, which was designed by d-electron alloy design theory and fabricated by spark plasma sintering, exhibits both low elastic modulus and high strength. However, its biocompatibility remains largely unclear. Methods : the microstructure of the (Ti–35Nb–7Zr–5Ta)98 Si2 alloy was examined by scanning electron microscopy. Its effects on fibroblast cell proliferation and osteoblast cell adhesion, morphology, differentiation, inflammatory response, apoptosis, and biomineralization were investigated in in vitro studies. The commercial Ti6 Al4 V alloy was studied side-by-side for comparison. Results : the (Ti–35Nb–7Zr–5Ta)98 Si2 alloy displayed a two-phase microstructure, in which isolated semi-round equiaxed intermetallic hexagonal (Ti, Zr)2 Si(S2) grains were dispersed within a continuous body-centered cubic (bcc) β-Ti matrix. Both phases were composed of ultrafine grains of several hundred nm. Similar to the Ti6 Al4 V alloy, the (Ti–35Nb–7Zr–5Ta)98 Si2 alloy exhibited low cytotoxicity towards L-929 fibroblasts and allowed effective MC3T3-E1 osteoblast attachment with no significant effects on cell differentiation, inflammatory response, apoptosis or biomineralization. Conclusion : this study demonstrates that the newly reported β-type titanium alloy (Ti–35Nb–7Zr–5Ta)98 Si2, which has been reported to exhibit improved mechanical properties displays excellent biocompatibility. Therefore, this alloy may be a superior implant material in biomedical implantation.