Copper-catalyzed direct C–H fluoroalkenylation of heteroarenes. Issue 1 (25th November 2015)

• Record Type: Journal Article
• Authors: Rousée, Kevin; Schneider, Cédric; Bouillon, Jean-Philippe; Levacher, Vincent; Hoarau, Christophe; Couve-Bonnaire, Samuel; Pannecoucke, Xavier
• Is Part Of: Organic & biomolecular chemistry. Volume 14:Issue 1(2016)
• Page Start: 353
• Page End: 357
• Publication Date: 2015-11-25
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c5ob02213d
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : Efficient copper-catalyzed direct C–H fluoroalkenylation of heterocycles using various gem -bromofluoroalkenes as electrophiles is reported for the first time. Abstract : Copper-catalyzed direct C–H fluoroalkenylation of heterocycles using various gem -bromofluoroalkenes as electrophiles is reported. This efficient method offers step-economical, low-cost and stereocontrolled access to relevant heteroarylated monofluoroalkenes. The synthesis of fluorinated analogues of biomolecules and therapeutic agents for the treatment of Duchenne muscular dystrophy as application is reported.