Hydroxylated fullerene-capped, vinblastine-loaded folic acid-functionalized mesoporous silica nanoparticles for targeted anticancer therapy. Issue 9 (18th January 2016)

• Record Type: Journal Article
• Authors: Knežević, Nikola Ž.; Mrđanović, Jasminka; Borišev, Ivana; Milenković, Sanja; Janaćković, Đorđe; Cunin, Frédérique; Djordjevic, Aleksandar
• Is Part Of: RSC advances. Volume 6:Issue 9(2016)
• Page Start: 7061
• Page End: 7065
• Publication Date: 2016-01-18
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c5ra22937e
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : Fullerenol and anticancer drug loaded pores of folic acid-functionalized mesoporous silica nanoparticles are showcased for targeted anticancer treatment. Abstract : A novel cancer-targeting drug delivery system is constructed and characterized, based on folic acid-functionalized mesoporous silica nanoparticles with pore-loaded anticancer drug vinblastine and pore-blocking fullerenol molecules. The selective treatment efficacy based on targeting of cancer-overexpressed folate receptors is demonstrated by comparison of cell viability upon the treatment of healthy MRC-5, breast cancer MCF-7 and cervical cancer HeLa cells, which are known to differ in the amount of folate receptors on their surfaces.