Vascular response to 1 week of sleep restriction in healthy subjects. A metabolic response?. (1st July 2015)

• Record Type: Journal Article
• Authors: Sauvet, Fabien; Drogou, Catherine; Bougard, Clément; Arnal, Pierrick J.; Dispersyn, Garance; Bourrilhon, Cyprien; Rabat, Arnaud; Van Beers, Pascal; Gomez-Merino, Danielle; Faraut, Brice; Leger, Damien; Chennaoui, Mounir
• Is Part Of: International journal of cardiology. Volume 190(2015)
• Page Start: 246
• Page End: 255
• Publication Date: 2015-07-01
• Subjects: MCH metacholine chloride -- B baseline (i.e., 8 h time in bed per night) -- CIV cathodal induced vasodilation -- COX cyclooxygenase -- DAP diastolic arterial pressure -- EDHF endothelium-derived hyperpolarizing factors -- HR heart rate -- MAP mean arterial pressure -- NO nitric oxide -- NOS nitric oxide synthase -- PU perfusion unit -- SAP systolic arterial pressure -- SR sleep restriction (i.e., 4 h time in bed per night) -- SkBF skin blood flow -- Tarm arm skin temperature -- TIB time in bed -- TST total sleep time -- Tco body temperature -- Tfi finger temperature; Sleep -- Inflammation -- Endothelial function -- Iontophoresis -- Laser doppler -- Sleep restriction; Cardiology -- Periodicals; Electronic journals; 616.12
• DOI: 10.1016/j.ijcard.2015.04.119
• Languages: English
• ISSNs: 0167-5273

Abstract

Abstract: Background: Sleep loss may induce endothelial dysfunction, a key factor in cardiovascular risk. We examined the endothelial function during one week of sleep restriction and a recovery period (from 3-to-13 days) in healthy subjects, and its link to autonomic, inflammatory and/or endocrine responses. Methods: 12 men were followed at baseline (B1, 8-h sleep), after 2 (SR2) and 6 (SR6) days of SR (4-h sleep: 02:00–06:00) and after 1 (R1) and 12 (R12) recovery nights (8 h sleep). At 10:00, we assessed changes in: arm cutaneous vascular conductance (CVC) induced by local application of methacholine (MCh), cathodal current (CIV) and heat (44 °C), finger CVC and skin temperature (Tfi) during local cold exposure (5 °C, 20-min) and passive recovery (22 °C, 20-min). Blood samples were collected at 08:00. Results: Compared with baseline (B1), MCh and heat-induced maximal CVC values (CVCpeak ) were decreased at SR6 and R1. No effect of SR was observed for Tfi and CVC during immersion whereas these values were lower during passive recovery on SR6 and R1. From SR2 to R12, plasma concentrations of insulin, IGF-1 (total and free) and MCP-1 were significantly increased while those of testosterone and prolactin were decreased. Whole-blood blood mRNA concentrations of TNF-α and IL-1β were higher than B1. No changes in noradrenaline concentrations, heart rate and blood pressure were observed. Conclusions: These results demonstrate that SR reduces endothelial-dependent vasodilatation and local tolerance to cold. This endothelial dysfunction is independent of blood pressure and sympathetic activity but associated with inflammatory and metabolic pathway responses (ClinicalTrials-NCT01989741 ). Highlights: We examine the impact of sleep restriction on endothelial function. One week of sleep restriction alters endothelial function in healthy subjects. We observed an inflammatory and metabolic response to sleep deprivation. No effect of sleep restriction on blood pressure or heart rate was observed. Changes persist after 2 recovery nights.