Cord blood insulin-like growth factor (IGF)-1, IGF-binding proteins and adiponectin, and birth size in offspring of women with mild gestational diabetes. (February 2016)

• Record Type: Journal Article
• Authors: Kanai, Yu; Kamoda, Tomohiro; Saito, Makoto; Fujiyama, Satoshi; Nishimura, Kazunori; Iwabuchi, Atsushi; Miyazono, Yayoi; Hamada, Hiromi; Sumazaki, Ryo
• Is Part Of: Early human development. Volume 93(2016)
• Page Start: 39
• Page End: 42
• Publication Date: 2016-02
• Subjects: Insulin-like growth factor -- Adiponectin -- Gestational diabetes mellitus; Fetus -- Periodicals; Neonatology -- Periodicals; Prenatal influences -- Periodicals; 612.65
• DOI: 10.1016/j.earlhumdev.2015.12.003
• Languages: English
• ISSNs: 0378-3782

Abstract

Abstract: Objective: To clarify the impact of a mild form of gestational diabetes mellitus (GDM) on neonatal birth size, and on insulin-related hormones and adiponectin (AdipoQ) in cord blood. Methods: Two hundred and sixteen Japanese pregnant women diagnosed as having normal glucose tolerance according to the JSOG criteria were enrolled. Of the 216 women, 38 women were reclassified into a mild GDM (mGDM) group according to the IADPSG criteria. Of the remaining 178 women, 135 women with normal 50-g glucose challenge test were reclassified into a normal glucose tolerance (NGT) group. Cord blood insulin-like growth factor (IGF)-1, IGF-binding proteins (IGFBPs) and AdipoQ were measured in the offspring of the two groups. Results: Birth weight and its SD scores were larger in the mGDM group than in the NGT group. The incidence of large-for-gestational age (LGA) newborns was higher in the mGDM than in the NGT group. No differences in cord blood free IGF-1, IGFBP-1, IGFBP-2 or AdipoQ levels were observed between the mGDM and NGT groups. Conclusions: Our study suggests that mild GDM reclassified according to the IADPSG criteria influences neonatal birth size, but neither the IGF-IGFBP axis nor AdipoQ can account for the changes of birth size in offspring of women with mild GDM. Highlights: We clarified the impact of mild GDM on neonatal birth size and insulin-related hormones. Mild GDM increases incidence of LGA, but not of macrosomia. Insulin-related hormones in cord blood are not changed by mild GDM. Neither IGF-IGFBP axis nor adiponectin can account for the change of birth size.