Target-triggered cascade recycling amplification for label-free detection of microRNA and molecular logic operations. Issue 2 (3rd November 2015)

• Record Type: Journal Article
• Authors: Bi, Sai; Ye, Jiayan; Dong, Ying; Li, Haoting; Cao, Wei
• Is Part Of: Chemical communications. Volume 52:Issue 2(2016)
• Page Start: 402
• Page End: 405
• Publication Date: 2015-11-03
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c5cc07046e
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A cascade recycling amplification (CRA) that implements cascade logic circuits with feedback amplification function is developed for label-free chemiluminescence detection of microRNA-122 with an ultrahigh sensitivity of 0.82 fM and excellent specificity, which is applied to construct a series of molecular-scale two-input logic gates by using microRNAs as inputs and CRA products as outputs. Abstract : A cascade recycling amplification (CRA) that implements cascade logic circuits with feedback amplification function is developed for label-free chemiluminescence detection of microRNA-122 with an ultrahigh sensitivity of 0.82 fM and excellent specificity, which is applied to construct a series of molecular-scale two-input logic gates by using microRNAs as inputs and CRA products as outputs.