A potent alpha-glucosidase inhibitor from Myristica cinnamomea King. (February 2016)

• Record Type: Journal Article
• Authors: Sivasothy, Yasodha; Loo, Kong Yong; Leong, Kok Hoong; Litaudon, Marc; Awang, Khalijah
• Is Part Of: Phytochemistry. Volume 122(2016:Feb.)
• Page Start: 265
• Page End: 269
• Publication Date: 2016-02
• Subjects: Myristica cinnamomea King -- Myristicaceae -- Dimeric acylphenol -- Acylphenol -- Giganteone D -- Cinnamomeone A -- α-Glucosidase inhibitor; Botanical chemistry -- Periodicals; Biochemistry -- Periodicals; Botany -- Periodicals; Chimie végétale -- Périodiques; 572.2
• DOI: 10.1016/j.phytochem.2015.12.007
• Languages: English
• ISSNs: 0031-9422

Abstract

Graphical abstract: A new dimeric acylphenol, giganteone D (1 ) and an unprecedented acylphenol, cinnamomeone A (2 ) isolated from the bark of Myristica cinnamomea King exhibit α-glucosidase inhibitory activity. Highlights: A dimeric acylphenol, giganteone D, was isolated from Myristica cinnamomea . The bark also yielded an acylphenol with an unprecedented skeleton, cinnamomeone A. Isolates were tested for their α-glucosidase inhibiting potential. Giganteone D was identified as a potent α-glucosidase inhibitor. Abstract: A dimeric acylphenol and a potent α-glucosidase inhibitor, giganteone D (IC50 5.05 μM), was isolated and characterized from the bark of Myristica cinnamomea King. The bark also yielded an acylphenol with an unprecedented skeleton for which the name cinnamomeone A (IC50 358.80 μM) was proposed. Their structures were established by means of NMR and MS spectrometric analyses. The Lineweaver–Burk plot of giganteone D indicated that it was a mixed-type inhibitor. This is the first report on the α-glucosidase inhibiting potential of acylphenols.