Immobilizing water-soluble graphene quantum dots with gold nanoparticles for a low potential electrochemiluminescence immunosensor. Issue 39 (22nd September 2015)

• Record Type: Journal Article
• Authors: Dong, Yongqiang; Wu, Huan; Shang, Pengxiang; Zeng, Xiaoting; Chi, Yuwu
• Is Part Of: Nanoscale. Volume 7:Issue 39(2015)
• Page Start: 16366
• Page End: 16371
• Publication Date: 2015-09-22
• Subjects: Nanoscience -- Periodicals; Nanotechnology -- Periodicals; 620.505
• DOI: 10.1039/c5nr04328j
• Languages: English
• ISSNs: 2040-3364

Abstract

Abstract : Nano-hybrids of hydrazide-modified graphene quantum dots (HM-GQDs)/gold nanoparticles (AuNPs) prepared from the redox reaction between HM-GQDs and AuCl4 − were used for electrochemiluminescent immunosensor of carcinoembryonic antigen. Abstract : Hydrazide-modified graphene quantum dots (HM-GQDs) obtained by refluxing GQDs with hydrazine hydrate were hybridized with gold nanoparticles (AuNPs) through a redox reaction between HM-GQDs and AuCl4 − . The obtained nano-hybrids (HM-GQD–AuNPs) possess the unique electrochemiluminescence (ECL) properties of HM-GQDs and the easy self-assembly with some bio-molecules of AuNPs, which have great potential applications in bio-sensors. HM-GQD–AuNPs were modified on a glassy carbon electrode to develop a novel ECL immunosensor of carcinoembryonic antigen (CEA) as a model target analyte. Due to the increment of electron-transfer resistance after immunoreaction, the ECL intensity decreased as the concentration of CEA was increased. The linear response range was between 0.02 and 80 ng mL −1, and the detection limit was 0.01 ng mL −1 .