Total synthesis of diverse oxygenated carbazoles by modified aromatization using molecular iodine. Issue 6 (10th February 2016)

• Record Type: Journal Article
• Authors: Humne, Vivek T.; Naykode, Mahavir S.; Ghom, Monica H.; Lokhande, Pradeep D.
• Is Part Of: Tetrahedron letters. Volume 57:Issue 6(2016)
• Page Start: 688
• Page End: 691
• Publication Date: 2016-02-10
• Subjects: Molecular iodine -- Aromatization -- 1-Oxygenated carbazoles -- 1, 6-Dioxygenated carbazoles; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2016.01.002
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Abstract: A convenient route has been developed for mono and dioxygenated carbazole alkaloids from 1-oxotetrahydrocarbazoles. The key step of the synthetic route is the aromatic process of 1-oxotetrahydrocarbazoles using molecular iodine. To our knowledge, this is the first report to manifest a direct synthesis of clausine E, mukonine, mukoeic acid and mukoline, from readily available ester-containing building blocks by using Fischer–Borsche method.