Rhodamine analogs for molecular ruler applications. (March 2016)

• Record Type: Journal Article
• Authors: Chu, Yu-Hsuan; Escobedo, Jorge O.; Jiang, Meiyan; Steyger, Peter S.; Strongin, Robert M.
• Is Part Of: Dyes and pigments. Volume 126(2016)
• Page Start: 46
• Page End: 53
• Publication Date: 2016-03
• Subjects: Molecular ruler -- Rhodamine -- Ion channel -- Pore dilation -- Near-infrared -- Texas red; Dyes and dyeing -- Periodicals; Pigments -- Periodicals; 667.2
• DOI: 10.1016/j.dyepig.2015.11.015
• Languages: English
• ISSNs: 0143-7208

Abstract

Abstract: A series of geometrically well-defined cationic fluorophores were designed based on molecular mechanics. They contain biaryl linkers to impart rigidity preventing intramolecular folding between a conjugated biomolecule and fluorophore. All probes have absorption and emission maxima within 20 nm from Texas Red, as predicted by TDDFT calculations and validated experimentally. Graphical abstract: Highlights: Extended rigid rhodamines were designed via molecular simulations. The trend of spectral properties of rhodamines agreed with TDDFT calculations. Amine-reactive probes for bioconjugation were synthesized. To be used as molecular ruler to study pore dilation in cationic channels.