'On water synthesis' of oxindoles bearing quaternary carbon center through C–H (sp3) functionalization of methyl azaarenes. Issue 5 (3rd February 2016)

• Record Type: Journal Article
• Authors: Yaragorla, Srinivasarao; Singh, Garima; Dada, Ravikrishna
• Is Part Of: Tetrahedron letters. Volume 57:Issue 5(2016)
• Page Start: 591
• Page End: 594
• Publication Date: 2016-02-03
• Subjects: 3, 3-Disubstituted oxindoles -- sp3 C–H functionalization -- On-water synthesis -- Multicomponent reactions -- Heterocyclic compounds; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2015.12.096
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Abstract: A catalyst-free and green approach of sp 3 C–H functionalization of methyl azaarenes with malononitrile and isatins for the synthesis of oxindole derivatives bearing quaternary carbon center has been described in water. This one-pot three component synthesis endures the key features like first 'on water synthesis', short reaction times, moderate to good yields, and large substrate scope.