An efficient one-pot protocol for the conversion of benzaldehydes into tetrazole analogs. Issue 5 (3rd February 2016)

• Record Type: Journal Article
• Authors: Khan, Khalid Mohammed; Fatima, Itrat; Saad, Syed Muhammad; Taha, Muhammad; Voelter, Wolfgang
• Is Part Of: Tetrahedron letters. Volume 57:Issue 5(2016)
• Page Start: 523
• Page End: 524
• Publication Date: 2016-02-03
• Subjects: One-pot synthesis -- Oximes -- Nitriles -- Tetrazoles; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2015.12.067
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Abstract: An efficient protocol has been developed for the one-pot synthesis of tetrazole derivatives in moderate to good yields starting from substituted benzaldehydes and proceeding via non-isolated oxime and nitrile intermediates. The structures of the desired products were confirmed by IR, and NMR spectroscopy as well as mass spectrometry. A plausible reaction mechanism is also discussed.