Palladium-catalyzed hydroaminocarbonylation of alkenes with amines promoted by weak acid. Issue 3 (20th January 2016)

• Record Type: Journal Article
• Authors: Zhang, Guoying; Ji, Xiaolei; Yu, Hui; Yang, Lei; Jiao, Peng; Huang, Hanmin
• Is Part Of: Tetrahedron letters. Volume 57:Issue 3(2016)
• Page Start: 383
• Page End: 386
• Publication Date: 2016-01-20
• Subjects: Palladium -- Hydroaminocarbonylation -- Alkenes -- Amines -- Amides; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2015.12.031
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Abstract: The weak acid has been identified as an efficient basicity-mask to overcome the basicity barrier imparted by aliphatic amines in the Pd-catalyzed hydroaminocarbonylation, which enables both aromatic and aliphatic amines to be applicable in the palladium-catalyzed hydroaminocarbonylation reaction. Notably, by using this protocol, the marketed herbicide of Propanil and drug of Fentanyl could be easily obtained in a one-pot manner.