A MLC-based inversely optimized 3D spatially fractionated grid radiotherapy technique. Issue 3 (December 2015)

• Record Type: Journal Article
• Authors: Jin, Jian-Yue; Zhao, Bo; Kaminski, Joseph M.; Wen, Ning; Huang, Yimei; Vender, John; Chetty, Indrin J.; Kong, Feng-Ming (Spring)
• Is Part Of: Radiotherapy and oncology. Volume 117:Issue 3(2015:Dec.)
• Page Start: 483
• Page End: 486
• Publication Date: 2015-12
• Subjects: Grid therapy -- Spatially fractionated radiotherapy -- Ablative radiation -- Immune-response -- Film dosimetry; Oncology -- Periodicals; Radiotherapy -- Periodicals; Tumors -- Periodicals; Medical Oncology -- Periodicals; Neoplasms -- radiotherapy -- Periodicals; Radiotherapy -- Periodicals; Radiothérapie -- Périodiques; Cancérologie -- Périodiques; Tumeurs -- Périodiques; Electronic journals; 616.9940642
• DOI: 10.1016/j.radonc.2015.07.047
• Languages: English
• ISSNs: 0167-8140

Abstract

Abstract: This study presents a MLC-based, 3D grid-therapy technique with characteristics of both 3D-conformal-radiotherapy and grid-therapy. It generates a brachytherapy-like dose distribution, with D50% of 20, 9.8, 5.4 and 2.9-Gy, for the spheres, target, 1 cm-outershell and 2 cm-outershell, respectively. It may provide a strategy to deliver ablative doses to large tumors safely.