Up-regulation of CYLD enhances Listeria monocytogenes induced apoptosis in THP-1 cells. (January 2016)

• Record Type: Journal Article
• Authors: Xu, Changzhi; Yang, Ling; Yuan, Yuan; Du, Fei; Wang, Shumin; Wang, Xiangfang; Zhu, Lin; Zhang, Buchang; Weaver, David
• Is Part Of: Microbial pathogenesis. Volume 90(2016)
• Page Start: 50
• Page End: 54
• Publication Date: 2016-01
• Subjects: Listeria monocytogenes -- CYLD -- Apoptosis; Pathogenic microorganisms -- Periodicals; Pathology, Molecular -- Periodicals; Communicable Diseases -- microbiology -- Periodicals; Communicable Diseases -- parasitology -- Periodicals; Micro-organismes pathogènes -- Périodiques; Pathologie moléculaire -- Périodiques; Electronic journals; 616.9041
• DOI: 10.1016/j.micpath.2015.10.007
• Languages: English
• ISSNs: 0882-4010

Abstract

Abstract: Listeria monocytogenes ( Lm ), a facultative anaerobic gram-positive bacterium, causes listeriosis. Immune cell apoptosis is considered to be one pathogenic factor for listeriosis. As a deubiquitinase, CYLD is an important regulator both in innate immune response and apoptosis by negatively modulating NF-κB pathway. However the role of CYLD in Lm induced apoptosis remains unclear. Here we found that CYLD is significantly up-regulated in macrophages upon its infection. There is a moderate decrease in Lm proliferation and apoptotic cells in siRNA-induced CYLD knockdown THP-1 cells. Thereby CYLD may be involved in cell apoptosis mediated by Lm infection and its proliferation.