Dietary Phaseolus vulgaris extract alleviated diet-induced obesity, insulin resistance and hepatic steatosis and alters gut microbiota composition in mice. (January 2016)

• Record Type: Journal Article
• Authors: Song, Haizhao; Han, Wen; Yan, Fujie; Xu, Dongdong; Chu, Qiang; Zheng, Xiaodong
• Is Part Of: Journal of functional foods. Volume 20(2016)
• Page Start: 236
• Page End: 244
• Publication Date: 2016-01
• Subjects: Phaseolus vulgaris extract -- Obesity -- Insulin resistance -- Hepatic steatosis -- Gut microbiota; Phaseolamin (PubChem CID: 91572) -- Chloroform (PubChem CID: 6212) -- Methanol (PubChem CID: 887) -- Glucose (PubChem CID: 5793) -- Haematoxylin (PubChem CID: 442514) -- Eosin yellowish (PubChem CID: 11048) -- Formaldehyde (PubChem CID: 91572) -- Dimethylbenzene (PubChem CID: 7259) -- Ethanol (PubChem CID: 702) -- Isopropanol (PubChem CID: 3776); Functional foods -- Analysis -- Periodicals; Food -- Biotechnology -- Periodicals; Nutrition -- Periodicals; 613.2
• DOI: 10.1016/j.jff.2015.10.022
• Languages: English
• ISSNs: 1756-4646

Abstract

Highlights: Phaseolus vulgaris extract administration reduced diet-induced body weight gain. Phaseolus vulgaris extract administration attenuated diet-induced hepatic steatosis. Phaseolus vulgaris extract improved glucose intolerance and insulin resistance. Phaseolus vulgaris extract administration modified the composition gut microbiota. Abstract: Phaseolus vulgaris may reduce appetite, body weight and gut microbiota and has been shown to contribute to the development of obesity, type 2 diabetes and non-alcoholic fatty liver disease. This study was conducted to investigate the impact of P. vulgaris extract (PVE) on obesity and obesity-associated metabolic syndromes, and determine whether the protective effects of PVE were associated with modulation of gut microbiota. C57BL/6J mice were fed low-fat diet, high-fat diet or high-fat diet supplemented with PVE of 50 mg/kg. The composition of gut microbiota was analysed by 16S rDNA sequencing. Our results showed that PVE treatment reduced body weight and improved hepatic steatosis and insulin resistance in high-fat diet-fed mice. PVE administration increased the relative abundance of Bifidobacterium, Lactobacillus and Akkermansia at the genus level. In conclusion, PVE protects from diet-induced obesity, insulin resistance and hepatic steatosis, and these beneficial effects were associated with the PVE-related modulation of gut microbiota.