Γ-Aminobutyric acid-rich yogurt fermented by Streptococcus salivarius subsp. thermophiles fmb5 apprars to have anti-diabetic effect on streptozotocin-induced diabetic mice. (January 2016)

• Record Type: Journal Article
• Authors: Chen, Lin; Zhao, Haizhen; Zhang, Chong; Lu, Yingjian; Zhu, Xiaoyu; Lu, Zhaoxin
• Is Part Of: Journal of functional foods. Volume 20(2016)
• Page Start: 267
• Page End: 275
• Publication Date: 2016-01
• Subjects: γ-Aminobutyric acid-rich yogurt -- Diabetes -- Blood glucose -- Insulin -- Streptozotocin-induced diabetic mice; γ-Aminobutyric acid (PubChem CID: 119) -- Streptozotocin (PubChem CID: 5300) -- Sodium glutamate (PubChem CID: 23689119) -- Citric acid (PubChem CID: 311) -- Glucose (PubChem CID: 5793) -- Paraformaldehyde (PubChem CID: 71309502) -- Haematoxylin (PubChem CID: 10603) -- Eosin (PubChem CID: 11048); SIDM streptozotocin-induced diabetic mice -- T1D type 1 diabetes -- GABA γ-aminobutyric acid -- GAD glutamate decarboxylase -- NOD non-obesity diabetes -- HFD high fat diet -- STZ streptozotocin -- TC total cholesterol -- TG triacylglycerol -- HDL-C high-density lipoprotein cholesterol -- LDL-C low-density lipoprotein cholesterol -- GSP glycosylated serum protein -- OGTT oral glucose tolerance test -- BG blood glucose -- AUC area under the curve -- BUN blood urea nitrogen -- H&E stain haematoxylin–eosin stain; Functional foods -- Analysis -- Periodicals; Food -- Biotechnology -- Periodicals; Nutrition -- Periodicals; 613.2
• DOI: 10.1016/j.jff.2015.10.030
• Languages: English
• ISSNs: 1756-4646

Abstract

Highlights: GABA-rich yogurt fermented is orally administrated to SIDM for the first time. Oral administration of GABA-rich yogurt ameliorates hyperglycaemia of SIDM. Oral administration of GABA-rich yogurt improves impaired glucose tolerance of SIDM. Oral administration of GABA-rich yogurt improves dyslipidaemia of SIDM. GABA-rich yogurt enhances the level of serum insulin and restores pancreas of SIDM. Abstract: γ-Aminobutyric acid (GABA)-rich yogurt is a novel type of functional fermented-dairy product in the market. This study investigated the anti-diabetic effects of GABA-rich yogurt fermented by Streptococcus salivarius subsp. thermophiles fmb5 on streptozotocin-induced diabetic mice (SIDM). SIDM was administered orally GABA-rich yogurt for six weeks. The results showed that oral administration of GABA-rich yogurt improved both hyperglycaemia and impaired glucose tolerance of SIDM with a dose-dependent effect. Notably, GABA-rich yogurt significantly decreased the concentrations of serum total cholesterol (TC) and triacylglycerol (TG), whereas remarkably increased the concentrations of high-density lipoprotein cholesterol (HDL-C) and insulin in serum of SIDM. Furthermore, GABA-rich yogurt normalised hypertrophy of liver and kidney and restored pancreas islet in SIDM. These results suggest that GABA-rich yogurt may be effective in improving type 1 diabetes (T1D) and delaying the progression of diabetes complications. GABA-rich yogurt could be a great functional dairy product with benefit for T1D patients.