CHD associated with syndromic diagnoses: peri-operative risk factors and early outcomes. (8th September 2015)

• Record Type: Journal Article
• Authors: Landis, Benjamin J.; Cooper, David S.; Hinton, Robert B.
• Is Part Of: Cardiology in the young. Volume 26:Number 1(2016)
• Page Start: 30
• Page End: 52
• Publication Date: 2015-09-08
• Subjects: CHD, -- syndrome, -- genetic; Pediatric cardiology -- Periodicals; 618.9212
• DOI: 10.1017/S1047951115001389
• Languages: English
• ISSNs: 1047-9511

Abstract

Abstract: CHD is frequently associated with a genetic syndrome. These syndromes often present specific cardiovascular and non-cardiovascular co-morbidities that confer significant peri-operative risks affecting multiple organ systems. Although surgical outcomes have improved over time, these co-morbidities continue to contribute substantially to poor peri-operative mortality and morbidity outcomes. Peri-operative morbidity may have long-standing ramifications on neurodevelopment and overall health. Recognising the cardiovascular and non-cardiovascular risks associated with specific syndromic diagnoses will facilitate expectant management, early detection of clinical problems, and improved outcomes – for example, the development of syndrome-based protocols for peri-operative evaluation and prophylactic actions may improve outcomes for the more frequently encountered syndromes such as 22q11 deletion syndrome.