Antithrombotic management in patients with atrial fibrillation undergoing coronary stent implantation: What is the impact of guideline adherence?. (15th January 2016)

• Record Type: Journal Article
• Authors: Ancedy, Yann; Lecoq, Coralie; Saint Etienne, Christophe; Ivanes, Fabrice; Angoulvant, Denis; Babuty, Dominique; Lip, Gregory Y.H.; Fauchier, Laurent
• Is Part Of: International journal of cardiology. Volume 203(2016)
• Page Start: 987
• Page End: 994
• Publication Date: 2016-01-15
• Subjects: ACS acute coronary syndrome -- AF atrial fibrillation -- APT antiplatelet therapy -- ATT antithrombotic therapy -- BMS bare metal stent -- CI confidence interval -- CABG coronary artery bypass graft -- CSS clinical SYNTAX score -- DES drug-eluting stent -- ESC European Society of Cardiology -- MACE major adverse cardiac event -- NSTEMI non-ST-elevation myocardial infarction -- OAC oral anticoagulation -- OR odds ratio -- PCI percutaneous coronary intervention -- STEMI ST-elevation myocardial infarction -- SYNTAX score SYNergy between PCI with TAXUS™ and cardiac surgery -- TE thromboembolic event; Atrial fibrillation -- Coronary stenting -- Guideline adherence -- Anticoagulant -- Antiplatelet agent; Cardiology -- Periodicals; Electronic journals; 616.12
• DOI: 10.1016/j.ijcard.2015.11.090
• Languages: English
• ISSNs: 0167-5273

Abstract

Abstract: Aims: Patients with atrial fibrillation (AF) who undergo percutaneous coronary intervention (PCI) and stenting require triple antithrombotic therapy according to current ESC guidelines. The purpose of this study was to assess guideline implementation and predictive factors of the prognosis related to ESC guideline adherence. Methods and results: We enrolled consecutive AF patients referred for PCI with stent from 2011 to 2014. Among 371 patients (72% male; mean age 76 ± 11) followed up for 505 ± 372 days (median 391, interquartile range 550 days), 118 (45%) undergoing elective coronary stenting and 41 (31%) among those with acute coronary syndrome were guideline adherent. Oral anticoagulation (OAC) before hospitalization was the only factor independently associated with guideline adherence (OR, 0.45; 95% CI 0.26–0.77; p = 0.003). OAC underuse and antiplatelet therapy (APT) underuse were independently associated with increased risks of death (OR 5.55; 95% CI 2.42–13.47; p < 0.0001 and OR 5.56; 95% CI, 2.17–14.65; p = 0.0004, respectively) and major adverse cardiac events (MACE) (OR 4.18; 95% CI 2.05–8.79; p < 0.0001 and OR 4.81; 95% CI, 2.09–11.18; p = 0.0002, respectively). Conclusion: Guidelines for antithrombotic therapy in patients with AF who undergo PCI and stent implantation are still poorly followed in clinical practice. OAC and APT underuse were both associated with an increased risk of death and MACE in this population. Highlights: Guidelines for anticoagulation are poorly followed in AF patients with PCI/stenting. Oral anticoagulation at baseline is the main predictor of guideline adherence. Anticoagulation and antiplatelet underuse are associated with a higher risk of MACE. Non-adherence to guidelines is also associated with a higher risk of bleeding.