Relationship between serum resistin concentrations with metabolic syndrome and its components in an Iranian population. Issue 4 (October 2015)

• Record Type: Journal Article
• Authors: Asgary, Sedigheh; SamsamShariat, Seyyed Ziaedin; Ghorbani, Ahmad; Keshvari, Mahtab; Sahebkar, Amirhossein; Sarrafzadegan, Nizal
• Is Part Of: Diabetes & metabolic syndrome. Volume 9:Issue 4(2015)
• Page Start: 266
• Page End: 270
• Publication Date: 2015-10
• Subjects: Adipokine -- Metabolic syndrome -- Resistin -- Cardiovascular disease; Diabetes -- Periodicals; Metabolism -- Disorders -- Periodicals; Diabetes Mellitus -- Periodicals; Metabolic Diseases -- Periodicals; Diabète -- Périodiques; Métabolisme, Troubles du -- Périodiques; Endocrinologie -- Périodiques; Diabète -- Physiopathologie -- Périodiques; Diabetes; Metabolism -- Disorders; Electronic journals; Periodicals; 616.462
• DOI: 10.1016/j.dsx.2014.09.007
• Languages: English
• ISSNs: 1871-4021

Abstract

Abstract: Background: The aim of the study is to determine the association of resistin with each MetS component. Methods: This study had a case-control design, and its data was retrieved from the Isfahan Healthy Heart Program (IHHP), Serum samples from 44 subjects with MetS (diagnosed according to the NCEP-ATPIII criteria) and 46 healthy controls were analyzed for resistin using enzyme-linked immunosorbent assay. Association between serum resistin and levels of total (TC), low- (LDL-C) and high-density (HDL-C) lipoprotein cholesterol, triglycerides (TG), fasting blood sugar (FBS), waist circumference, body mass index, and systolic and diastolic blood pressures was determined. Results: Serum resistin levels were significantly higher in the MetS compared with control group (3.64 ± 1.63, P = 0.040). Serum levels of resistin were found to be significantly correlated with levels of TC ( r = −0.347; P = 0.027) and LDL-C ( r = −0.311; P = 0.050), but not other components of MetS including systolic and diastolic blood pressure, TG, HDL-C and FBS ( P > 0.05) in the MetS group, after adjustment for age, gender and BMI. No significant correlation between resistin and MetS components was observed in the control group ( P > 0.05). Conclusion: Serum resistin levels are elevated in subjects with MetS and may be associated with the severity of this syndrome.