Family association study between melatonin receptor gene polymorphisms and polycystic ovary syndrome in Han Chinese. (December 2015)

• Record Type: Journal Article
• Authors: Song, X.; Sun, X.; Ma, G.; Sun, Y.; Shi, Y.; Du, Y.; Chen, Zi-Jiang
• Is Part Of: European journal of obstetrics, gynecology, and reproductive biology. Volume 195(2015:Dec.)
• Page Start: 108
• Page End: 112
• Publication Date: 2015-12
• Subjects: Polycystic ovary syndrome -- Transmission disequilibrium test -- Melatonin receptor -- Single nucleotide polymorphism; Obstetrics -- Periodicals; Gynecology -- Periodicals; Reproductive health -- Periodicals; Gynecology -- Periodicals; Obstetrics -- Periodicals; Reproduction -- Periodicals; Obstétrique -- Périodiques; Gynécologie -- Périodiques; Reproduction -- Périodiques; Verloskunde; Gynaecologie; Voortplanting (biologie); Gynecology; Obstetrics; Reproduction; Electronic journals; Periodicals; Electronic journals; 618.05
• DOI: 10.1016/j.ejogrb.2015.09.043
• Languages: English
• ISSNs: 0301-2115

Abstract

Abstract: Objective: The melatonin receptor (MTNR) gene, reported to be associated with insulin sensitivity, diabetes and metabolic syndrome, could be a plausible candidate gene for polycystic ovary syndrome (PCOS). This study was designed to investigate whether an association exists between two single nucleotide polymorphism (SNP) variants (rs2119882 and rs10830963) of the MTNR gene and PCOS in Han Chinese. Study design: In total, 263 family trios (789 participants) were enrolled in this family-based transmission disequilibrium test (TDT). Genotypes were obtained by sequencing. In total, 135 trios of rs2119882 and 127 trios of rs10830963 were tested. Results: An association was detected between rs2119882 ( p = 0.0209) and PCOS, suggesting that the MTNR gene may indicate increased susceptibility to PCOS in Chinese. No significant association was found for rs10830963 (transmitted:non-transmitted = 76:51, p = 0.1573). The association between the MTNR gene variants and clinical characteristics of women with PCOS was investigated. CC genotype carriers had higher levels of clinical and metabolic features than the TC and TT genotypes. A significant difference in transmission of allele C of rs2119882 was found between obese and non-obese women with PCOS (Chi-squared = 5.5983, p = 0.018). Conclusion: This study may provide a basis for further studies of the MTNR gene in the aetiology of PCOS.