Antidiabetic properties of lyophilized extract of acorn (Quercus brantii Lindl.) on experimentally STZ-induced diabetic rats. (24th December 2015)

• Record Type: Journal Article
• Authors: Dogan, Abdulahad; Celik, Ismail; Kaya, Mehmet Salih
• Is Part Of: Journal of ethnopharmacology. Volume 176(2015)
• Page Start: 243
• Page End: 251
• Publication Date: 2015-12-24
• Subjects: Thiobarbituric acid (TBA) (PubChem CID: 2723628) -- Butylated hydroxytoluene (BHT) (PubChem CID: 31404) -- Trichloroacetic acid (TCA) (PubChem CID: 6421) -- Ethylenediaminetetraacetic acid (EDTA) (PubChem CID: 6049) -- Reduced glutathione (GSH) (PubChem CID: 124886) -- 5, 5′-dithiobis-(2-nitrobenzoic acid) (DTNB) (PubChem CID: 6254) -- 1-chloro-2, 4-dinitrobenzene (CDNB) (PubChem CID: 6) -- Oxidized glutathione (GSSG) (PubChem CID: 65359) -- β-Nicotinamide adenine dinucleotide phosphate (NADPH) (PubChem CID: 5884) -- Streptozotocin (STZ) (PubChem CID: 29327); Acorn -- Diabetes mellitus -- Oxidative stress -- Serum biomarkers -- Antioxidant defense system -- Malondialdehyde -- Rats; ADSC antioxidant defense system constituents -- ALP alkalane phosphatase -- ALT alanine aminotransferase -- AST aspartate aminotransferase -- CAT catalase -- CRE creatinine -- DB diabetic biomarkers -- DM diabetic mellitus -- DM+AC diabetes mellitus+Acarbose -- DM+QB diabetes mellitus+Quercus brantii -- GR glutathione reductase -- GSH reduced glutathine -- GSH-Px glutathione peroxidase -- GST glutathione S-transferase -- HbA1c glucosylated hemoglobin -- HDL-c high density lipoprotein-cholesterol -- HRDB hepatic and renal damage biomarkers -- LDH lactate dehydrogenase -- LDL-c low density lipoprotein-cholesterol -- LDSE liver damage serum enzymes -- LP lipid profile -- MDA malondialdehyde -- QB Quercus brantii -- SOD superoxide dismutase -- STZ streptozotocin -- TC total cholesterol -- TG total triglyceride; Ethnopharmacology -- Periodicals; Pharmacognosy -- Periodicals; Herbs -- Periodicals; Herbs -- Periodicals; Pharmacognosy -- Periodicals; Pharmacognosie -- Périodiques; Herbes -- Périodiques; 615.1
• DOI: 10.1016/j.jep.2015.10.034
• Languages: English
• ISSNs: 0378-8741

Abstract

Abstract: Ethnopharmacological relevance: Acorn obtained from the Quercus brantii Lindl. (QB) tree has been used in Turkish folk medicine. Some studies have reported as an antioxidant, antimicrobial, anti-inflammatory, gastroprotective, antitumoural of QB properties previously. however, its effect on the management of type diabetic 2 and oxidative stress complications is still unexplored. The aims of our study were the evaluation of the protective effect and antioxidant role of acorn lyophilized seed plant extract against STZ-induced diabetic complications as oxidative stress, hepatotoxicity and nephropathy, lipidemia and serum biomarkers of diabetes (SBD). Materials and methods: In-vivo studies were performed on STZ-induced diabetic rats Experiment was designed as I [Normal Control (NC)], II [ Diabetes mellitus (DM)], III [DM+Acarbose (20 mg/kg b.w) (DM+AC-20)], IV [DM+QB (100 mg/kg b.w) (DM+QB-100)], V [DM+QB (250 mg/kg b.w) (DM+QB-250)] and VI [DM+QB (500 mg/kg b.w) (DM+QB-500)] groups. Results: This study showed that the biochemical analysis showed a considerable increase in the HRDB, DB, LP, MDA and fluctuated ADSC in the II group as compared to that of control group whereas, AC and the plant lyophilized seed plant extract supplementations diet restored the STZ-induced diabetic complications towards the control. α-glycosidase activity in DM group showed statistically significant increase with respect to control group in small intestine. Moreover, in accordance with the effects of seed extract; in diabetic rat groups to whom acorn seed extract and acarbose were given, the levels of almost all the concerned parameters were reached to the ones measured at control group. As a result, it was concluded that acorn seed extract had certain healing effects on many complications caused by diabetes. Graphical abstract: