Impact of antifungal prescription on relative distribution and susceptibility of Candida spp. – Trends over 10 years. Issue 1 (January 2016)

• Record Type: Journal Article
• Authors: Bailly, Sébastien; Maubon, Danièle; Fournier, Pierre; Pelloux, Hervé; Schwebel, Carole; Chapuis, Claire; Foroni, Luc; Cornet, Muriel; Timsit, Jean-François
• Is Part Of: Journal of infection. Volume 72:Issue 1(2016)
• Page Start: 103
• Page End: 111
• Publication Date: 2016-01
• Subjects: Candidiasis -- Antifungal -- Echinocandins -- Resistance -- Candida glabrata -- ICU -- Antifungal stewardship -- Azoles -- Polyenes; ICU intensive care unit -- DDD defined daily dose -- HD hospital days -- MIC minimum inhibitory concentration -- SAT systemic antifungal treatment -- ARIMA autoregressive integrated moving average -- SD standard deviation; Infection -- Periodicals; Bacterial Infections -- Periodicals; Communicable Diseases -- Periodicals; Electronic journals; 616.905
• DOI: 10.1016/j.jinf.2015.09.041
• Languages: English
• ISSNs: 0163-4453

Abstract

Summary: Introduction: The incidence of Candida spp. infections is worrisome, particularly in critically ill patients. Previous reports suggested that increasing use of antifungal therapy might affect resistance profiles of invasive strains. The study objective was to describe the distribution resistance profile of Candida spp. strains, and to correlate it with antifungal consumptions within one ICU. Method: Antifungal drug consumption was measured as the number of defined daily doses per 1000 hospital days. The distribution of Candida spp. over a 10 year period 2004–2013 and the MICs of antifungal drugs over 2007–2013 were determined. Time series analyses were performed. Results: Of 2403 identified Candida spp. from 5360 patients, Candida albicans predominated (53.1%), followed by Candida glabrata (16.2%), Candida parapsilosis (7.9%) and Candida tropicalis (7.5%). C. parapsilosis increased from 5.7% in 2004 to 8.4% in 2013 (P = 0.02). The increase in caspofungin use is correlated with the increase in caspofungin MICs of C. parapsilosis (P = 0.01), C. glabrata (P = 0.001) and C. albicans (P = 0.02). Polyenes consumption correlated with an increase in amphotericin B MICs of C. glabrata (P = 0.04). Conclusion: Previous history of antifungal prescription within an ICU influences Candida species distribution and susceptibility profile to antifungal agents. The significant selective pressure exerted by caspofungin and amphotericin B on C. glabrata is a concern.