Can physiologic menstrual cycle change serum lamotrigine concentration?. (December 2015)

• Record Type: Journal Article
• Authors: Asadollahi, Marjan; Ramezani, Mahtab; Karimialavijeh, Ehsan; Tavakolian, Mehrnaz; Ramezani, Maryam
• Is Part Of: Seizure. Volume 33(2015)
• Page Start: 35
• Page End: 37
• Publication Date: 2015-12
• Subjects: Lamotrigine -- Serum concentration -- Estradiol -- Epilepsy; Epilepsy -- Periodicals; Epilepsy -- Periodicals; Seizures -- Periodicals; Épilepsie -- Périodiques; Electronic journals; Electronic journals; 616.853
• DOI: 10.1016/j.seizure.2015.10.003
• Languages: English
• ISSNs: 1059-1311

Abstract

Highlights: Serum lamotrigine levels were measured in women with epilepsy. Measurement was done in the luteal and follicular phases of the menstrual cycle. The serum level of LTG does not change significantly during the menstrual cycle. Abstract: Purpose: The present study aimed to compare the serum LTG levels during the early-/mid-follicular (low estradiol) and mid-luteal (high estradiol) phases of the physiologic menstrual cycle. Method: In a cross-sectional study, 20 women with epilepsy were recruited. Participants had been on monotherapy with LTG for at least two months. All the subjects had normal menstrual cycles. Blood samples for each patient were taken whilst fasting during the early-/mid-follicular (Days 3–5) and mid-luteal phases (Days 20–24). All samples were analyzed in batched assays. A comparison of the serum LTG levels was carried out using the Mann–Whitney U test Data were analyzed with the SPSS program, version 16 (SPSS Inc., Chicago, IL), p -values below 0.05 were considered significant. Results: The mean serum LTG levels for the early-/mid-follicular and mid-luteal phases were 4.28 ± 2.76 mg/ml (SD) and 3.86 ± 2.06 mg/ml (SD), respectively. There was no statistically significant difference in serum LTG level between the (low estradiol) early-/mid-follicular and (high estradiol) mid-luteal phases in our patients ( p -value = 0.23). Conclusion: The serum level of LTG does not alter significantly during the menstrual cycle.