A7RC peptide modified paclitaxel liposomes dually target breast cancer. (20th August 2015)
- Record Type:
- Journal Article
- Title:
- A7RC peptide modified paclitaxel liposomes dually target breast cancer. (20th August 2015)
- Main Title:
- A7RC peptide modified paclitaxel liposomes dually target breast cancer
- Authors:
- Cao, Jingyan
Wang, Ran
Gao, Ning
Li, Minghui
Tian, Xuyu
Yang, Weili
Ruan, Ying
Zhou, Chunlan
Wang, Guangtian
Liu, Xiaoying
Tang, Shukun
Yu, Yan
Liu, Ying
Sun, Guangyu
Peng, Haisheng
Wang, Qun - Abstract:
- Abstract : A7RC enhanced the accumulation of paclitaxel liposomes in a neuropilin-1 high expressing breast cancer mouse model and inhibited tumor growth and angiogenesis. Abstract : A7R peptide (ATWLPPR), a ligand of the NRP-1 receptor, regulates the intracellular signal transduction related to tumor vascularization and tumor growth. Here, we designed A7R-cysteine peptide (A7RC) surface modified paclitaxel liposomes (A7RC-LIPs) to achieve targeting delivery and inhibition of tumor growth and angiogenesis simultaneously. The cytotoxicity, inhibiting angiogenesis, and internalization of various liposomes by cells were assessed in vitro to confirm the influence of the peptide modification. The accumulations of A7RC-LIPs in various xenografts in mice were tracked to further identify the function of the peptide on the liposomes' surface. The results confirmed that A7RC peptides could enhance the uptake of vesicles by MDA-MB-231 cells, leading to stronger cytotoxicity in vitro and higher accumulation of vesicles in MDA-MB-231 xenografts in vivo . In addition, A7RC peptides enhanced the inhibitory effects of LIPs on the HUVEC tubular formation on Matrigel. The A7RC-LIPs may be promising drug carriers for anticancer therapy.
- Is Part Of:
- Biomaterials science. Volume 3:Number 12(2015:Dec.)
- Journal:
- Biomaterials science
- Issue:
- Volume 3:Number 12(2015:Dec.)
- Issue Display:
- Volume 3, Issue 12 (2015)
- Year:
- 2015
- Volume:
- 3
- Issue:
- 12
- Issue Sort Value:
- 2015-0003-0012-0000
- Page Start:
- 1545
- Page End:
- 1554
- Publication Date:
- 2015-08-20
- Subjects:
- Biomedical materials -- Periodicals
610.28 - Journal URLs:
- http://pubs.rsc.org/en/journals/journalissues/bm ↗
http://www.rsc.org/ ↗ - DOI:
- 10.1039/c5bm00161g ↗
- Languages:
- English
- ISSNs:
- 2047-4830
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 2087.724000
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 1388.xml