A copper(II) complex with pyridine-2, 6-dicarboxylic acid: Synthesis, characterization, thermal decomposition, bioactivity and interactions with herring sperm DNA. (4th November 2015)

• Record Type: Journal Article
• Authors: Zang, Qing; Zhong, Guo-Qing; Wang, Mei-Ling
• Is Part Of: Polyhedron. Volume 100(2015)
• Page Start: 223
• Page End: 230
• Publication Date: 2015-11-04
• Subjects: Pyridine-2, 6-dicarboxylic acid -- Copper(II) complex -- X-ray crystal structure -- TGA-FTIR -- Biological activity; Chemistry, Inorganic -- Periodicals; Chimie inorganique -- Périodiques; Organometaalverbindingen; Anorganische chemie; 546.05
• DOI: 10.1016/j.poly.2015.08.007
• Languages: English
• ISSNs: 0277-5387

Abstract

Graphical abstract: The copper(II) complex of pyridine-2, 6-dicarboxylic acid was synthesized and characterized by elemental analyses, single crystal X-ray diffraction, FTIR and TGA-FTIR. The interactions of the complex with herring sperm DNA was studied by means of spectral methods using acridine orange as a fluorescence probe. Abstract: The copper(II) complex of pyridine-2, 6-dicarboxylic acid was synthesized and characterized by elemental analyses, single crystal X-ray diffraction, FTIR and UV–Vis spectra, and thermogravimetric analysis coupled with infrared spectrometry (TGA-FTIR). The results show that the crystal structure of the complex belongs to the triclinic system, and the Cu(II) ion is five-coordinated by one pyridine N atom, two carboxylate O atoms from the ligand anion and two O atoms from two water molecules, forming a distorted triangular bipyramidal geometry. Under the conditions of a physiological pH environment, the interaction of the complex with herring sperm DNA was studied by means of spectral methods using acridine orange as a fluorescence probe. The bonding mode between the complex and DNA is evidenced to be intercalative binding, and the binding of the complex to DNA is driven by entropy.