Comparison of hemostatic sealants on ovarian reserve during laparoscopic ovarian cystectomy. (November 2015)

• Record Type: Journal Article
• Authors: Kang, Jun Hyeok; Kim, Yong Seok; Lee, San Hui; Kim, Woo Young
• Is Part Of: European journal of obstetrics, gynecology, and reproductive biology. Volume 194(2015:Nov.)
• Page Start: 64
• Page End: 67
• Publication Date: 2015-11
• Subjects: Ovarian reserve -- Ovarian cystectomy -- Hemostatic sealant -- Pathologic type -- Serum AMH level; Obstetrics -- Periodicals; Gynecology -- Periodicals; Reproductive health -- Periodicals; Gynecology -- Periodicals; Obstetrics -- Periodicals; Reproduction -- Periodicals; Obstétrique -- Périodiques; Gynécologie -- Périodiques; Reproduction -- Périodiques; Verloskunde; Gynaecologie; Voortplanting (biologie); Gynecology; Obstetrics; Reproduction; Electronic journals; Periodicals; Electronic journals; 618.05
• DOI: 10.1016/j.ejogrb.2015.08.010
• Languages: English
• ISSNs: 0301-2115

Abstract

Abstract: Objective: To determine whether different methods of hemostasis and pathologic subtypes would lead to significant differences regarding ovarian reserve after laparoscopic ovarian cystectomy. Study design: Data were prospectively collected from 129 patients who underwent laparoscopic ovarian cystectomy with either a hemostatic sealant (FloSeal or TachoSil) or bipolar coagulation to achieve hemostasis. Serum anti-Müllerian hormone (AMH) levels as measured by enzyme immunoassay. Measurements were made preoperatively and at 3 months postsurgery in each group [bipolar coagulator group ( n = 43), FloSeal group ( n = 46), and TachoSil group ( n = 40)]. Results: Age, BMI, parity, sociodemographic variables, and preoperative AMH levels were similar between the three groups of patients. At 3 months post-surgery, the AMH decline rate was significantly greater in the bipolar coagulation group compared with the two hemostatic sealant groups (41.2% [IQR, 16.7–52.4] vs. 15.4% [IQR, 5.2–41.9], respectively; P = 0.003). However, the AMH decline rates of the two hemostatic sealant groups (FloSeal and TachoSil) were not significantly different (15.4% [IQR, 7.8–44.6] vs. 15.9% [IQR, 0.7–41.1], P = 0.962). Also, subgroup analysis according to ovarian cyst type revealed no significant differences in the rate of serum AMH decline regardless of the hemostatic method (bipolar group, P = 0.30; FloSeal group, P = 0.47, and TachoSil group, P = 0.79). Conclusion: The two hemostatic sealants (FloSeal and Tachosil) did not exhibit any significant differences regarding the preservation of ovarian reserve regardless of ovarian cyst type.