Computational models of ventilator induced lung injury and surfactant dysfunction. (2015)

• Record Type: Journal Article
• Authors: Bates, Jason H.T.; Smith, Bradford J.; Allen, Gilman B.
• Is Part Of: Drug discovery today. Volume 15(2015)
• Page Start: 17
• Page End: 22
• Publication Date: 2015
• Subjects: Drug development -- Periodicals; Physiology, Pathological -- Periodicals; Drugs -- Testing -- Periodicals; Diseases -- Animal models -- Evaluation -- Periodicals; 616.027
• DOI: 10.1016/j.ddmod.2014.02.005
• Languages: English
• ISSNs: 1740-6757

Abstract

Abstract : Managing acute respiratory distress syndrome (ARDS) invariably involves the administration of mechanical ventilation, the challenge being to avoid the iatrogenic sequellum known as ventilator-induced lung injury (VILI). Devising individualized ventilation strategies in ARDS requires that patient-specific lung physiology be taken into account, and this is greatly aided by the use of computational models of lung mechanical function that can be matched to physiological measurements made in a given patient. In this review, we discuss recent models that have the potential to serve as the basis for devising minimally injurious modes of mechanical ventilation in ARDS patients.