Potential of boron neutron capture therapy (BNCT) for malignant peripheral nerve sheath tumors (MPNST). (December 2015)

• Record Type: Journal Article
• Authors: Fujimoto, Takuya; Andoh, Tooru; Sudo, Tamotsu; Fujita, Ikuo; Fukase, Naomasa; Takeuchi, Tamotsu; Sonobe, Hiroshi; Inoue, Masayoshi; Hirose, Tkanori; Sakuma, Toshiko; Moritake, Hiroshi; Sugimoto, Tohru; Kawamoto, Teruya; Fukumori, Yoshinobu; Yamamoto, Satomi; Atagi, Shinji; Sakurai, Yoshinori; Kurosaka, Masahiro; Ono, Koji; Ichikawa, Hideki; Suzuki, Minoru
• Is Part Of: Applied radiation and isotopes. Volume 106(2015:Dec.)
• Page Start: 220
• Page End: 225
• Publication Date: 2015-12
• Subjects: Malignant peripheral nerve sheath tumors (MPNST) -- NF1 -- Clear cell sarcoma -- HS-Sch-2 -- Boron neutron capture therapy (BNCT) -- p-Borono-L-phenylalanine; Radiology -- Periodicals; Radiation -- Industrial applications -- Periodicals; Nuclear chemistry -- Periodicals; Internet resource; Periodical; 660.298
• DOI: 10.1016/j.apradiso.2015.07.059
• Languages: English
• ISSNs: 0969-8043

Abstract

Abstract: Malignant peripheral nerve sheath tumors (MPNST) are relatively rare neoplasms with poor prognosis. At present there is no effective treatment for MPNST other than surgical resection. Nonetheless, the anti-tumor effect of boron neutron capture therapy (BNCT) was recently demonstrated in two patients with MPNST. Subsequently, tumor-bearing nude mice subcutaneously transplanted with a human MPNST cell line were injected with p -borono-L -phenylalanine (L -BPA) and subjected to BNCT. Pathological studies then revealed that the MPNST cells were selectively destroyed by BNCT. Highlights: MPNST responds to no effective treatment method other than surgery. Two clinical cases of MPNST demonstrated the efficacy of BNCT. MPNST cells and the MPNST-bearing animal model showed high uptake of boron. The results demonstrated the efficacy of BNCT for MPNST.