Top value platform chemicals: bio-based production of organic acids. (December 2015)

• Record Type: Journal Article
• Authors: Becker, Judith; Lange, Anna; Fabarius, Jonathan; Wittmann, Christoph
• Is Part Of: Current opinion in biotechnology. Volume 36(2015)
• Page Start: 168
• Page End: 175
• Publication Date: 2015-12
• Subjects: Biotechnology -- Periodicals; 660.6
• DOI: 10.1016/j.copbio.2015.08.022
• Languages: English
• ISSNs: 0958-1669

Abstract

Graphical abstract: Highlights: High-value organic acids range from carbon-two to carbon-six molecules. Engineered microbial cells reach titers of more than 200 g/L of organic acids. Production from renewables feeds into the value chain for fully bio-based plastics. Organic acids display a fast growing industrial market in biotechnology. Synthetic metabolic engineering extends to artificial pathways and non-natural chemicals. Abstract : Driven by the quest for sustainability, recent years have seen a tremendous progress in bio-based production routes from renewable raw materials to commercial goods. Particularly, the production of organic acids has crystallized as a competitive and fast-evolving field, related to the broad applicability of organic acids for direct use, as polymer building blocks, and as commodity chemicals. Here, we review recent advances in metabolic engineering and industrial market scenarios with focus on organic acids as top value products from biomass, accessible through fermentation and biotransformation.