Assessment of the effect of cyclosporine-A 0.05% emulsion on the ocular surface and corneal sensation following cataract surgery. Issue 1 (February 2016)

• Record Type: Journal Article
• Authors: Hamada, Samer; Moore, Tara C.B.; Moore, Jonathan E.; Al-Dreihi, Madonna G.; Anbari, Anas; Shah, Sunil
• Is Part Of: Contact lens & anterior eye. Volume 39:Issue 1(2016)
• Page Start: 15
• Page End: 19
• Publication Date: 2016-02
• Subjects: Cyclosporine-A -- Corneal sensation -- Cataract surgery -- Ocular surface -- Corneal nerves recovery -- Anti-inflammatory; Anterior segment (Eye) -- Periodicals; Contact lenses -- Periodicals; Segment antérieur (Œil) -- Périodiques; Lentilles de contact -- Périodiques; 617.752305
• DOI: 10.1016/j.clae.2015.07.003
• Languages: English
• ISSNs: 1367-0484

Abstract

Highlights: Cyclosporine-A drops is effective in reducing dry eye status after cataract surgery. Cyclosporine-A drops speed up return of corneal sensitivity after cataract surgery. Cyclosporine-A drops should be considered for all patients after cataract surgery. Abstract: Aim: To assess the effect of cyclosporine-A (CsA) 0.05% ophthalmic emulsion on corneal sensation and ocular surface problems following cataract surgery. Design: Prospective, randomized, double masked clinical trial. Methods: Consecutive case series of patients attending for bilateral cataract surgery. Subject's eyes were randomized to receive either topical CsA or carboxymethylcellulose 0.5% (CMC) eye drops twice daily for one month following routine cataract surgery. Subjective and objective assessments were performed pre-operatively, one week, and one month after surgery. Primary safety parameters included best spectacle-corrected visual acuity and incidence of adverse events. Objective assessments included tests of tear film (osmolarity, tear break-up time, and Schirmer's type-I test), ocular surface staining, corneal sensitivity and a subjective assessment: ocular surface disease index (OSDI) questionnaire. Results: 30 subjects (60 eyes) were recruited. At one month following cataract surgery, osmolarity, ocular surface staining, TBUT, Schirmer's results showed a greater improvement after CsA drops compared to CMC and this was statistically significant for all measures ( p < 0.05). All corneal sensation measurements were reduced after one week and one month. Eyes receiving CsA had higher recovery of corneal sensation at both time points post operatively and this was statistically significant at one month. OSDI questionnaire results did not show a statistically significant difference between the two eyes. Conclusions: CsA is effective and safe in the management of ocular surface problems after cataract surgery and allows faster recovery of corneal sensation. This recovery of sensation may be relevant to the improvement in ocular surface problems in all patients.