Pulmonary perfusion imaging: Qualitative comparison of TCIR MRI and SPECT/CT in porcine lung. Issue 12 (December 2015)

• Record Type: Journal Article
• Authors: Gaass, Thomas; Bauman, Grzegorz; Biederer, Jürgen; Hintze, Christian; Schneider, Moritz; Dinkel, Julien
• Is Part Of: European journal of radiology. Volume 84:Issue 12(2015)
• Page Start: 2646
• Page End: 2653
• Publication Date: 2015-12
• Subjects: Animal experimentation -- Magnetic resonance imaging -- Lung -- Blood volume; Medical radiology -- Periodicals; Radiology -- Periodicals; Radiologie médicale -- Périodiques; Medical radiology; Periodicals; 616.075705
• DOI: 10.1016/j.ejrad.2015.08.017
• Languages: English
• ISSNs: 0720-048X

Abstract

Abstract : Highlights: Evaluation of two-compartment inversion recovery in a multimodal animal MRI-study. Qualitative comparison of TCIR shows similar blood distribution as gold standard. Delineation and homogeneity of TCIR comparable or superior to standard methods. Abstract: Objectives: To validate the anatomical accuracy, homogeneity and sensitivity of two-compartment modeled inversion recovery (TCIR) magnetic resonance imaging (MRI) in a multimodal animal experiment as a non-invasive alternative to standard functional imaging techniques. Methods: Seven pigs were studied on a 1.5 T whole-body MR scanner and SPECT/CT. The specimens were intubated and maintained in general anesthesia throughout the experiment. TCIR maps of the fractional pulmonary blood volume were compared to dynamic contrast enhanced MRI and SPECT/CT via a region of interest (ROI) based reader study. A comprehensive statistical analysis was performed on the coefficient of variation to evaluate homogeneity properties. Sensitivity was assessed by detecting gravitation dependent perfusion variation and delineation of pathological areas. Results: The fPBV-maps of all examined specimens indicate a superior homogeneity in the computed values ( p < 1.3 × 10 −4 ). The sensitivity of the TCIR maps to a gravitation effect on the blood distribution was verified and a similar anteroposterior signal and count dependency was observed in DCE MRI and SPECT. Bland–Altman analysis showed no significant intra- or inter-observer difference within the ROI reader study ( p > 0.06). Conclusion: Superior information content, significantly higher homogeneity and similar sensitivity of TCIR when compared to DCE and SPECT/CT demonstrated the feasibility of TCIR MRI as an alternative contrast agent-free, non-invasive functional lung imaging approach.