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Modulation of ROS production in photodynamic therapy using a pH controlled photoinduced electron transfer (PET) based sensitiser. Issue 94 (5th October 2015)
Record Type:
Journal Article
Title:
Modulation of ROS production in photodynamic therapy using a pH controlled photoinduced electron transfer (PET) based sensitiser. Issue 94 (5th October 2015)
Main Title:
Modulation of ROS production in photodynamic therapy using a pH controlled photoinduced electron transfer (PET) based sensitiser
Abstract : Compound4 has been developed as a pH dependent sensitiser for use in photodynamic therapy. Abstract : A new sensitiser (4 ) for use in photodynamic therapy (PDT) has been developed to enable control of ROS production as a function of pH. This pH dependent PDT behaviour was tested in HeLa cells and in SCID mice bearing human xenograft pancreatic cancer (BxPC-3) tumours.