A turn-on fluorescent probe for hydrogen sulfide and its application in living cells. Issue 105 (13th October 2015)

• Record Type: Journal Article
• Authors: Zhao, Miao; Li, Hua; Li, Hui; Qiao, Qinglong; Cao, Cheng; Xu, Zhaochao
• Is Part Of: RSC advances. Volume 5:Issue 105(2015)
• Page Start: 86355
• Page End: 86358
• Publication Date: 2015-10-13
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c5ra15384k
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : Herein, we described a probe for H2 S detection based on the reduction of azide to amine. This probe was highly sensitive and selective toward H2 S and successfully applied for H2 S fluorescent imaging in living cells. Abstract : Hydrogen sulfide (H2 S) is an important endogenous signalling molecule in cellular physiology and pathology. Accordingly, sensitive, selective and reliable methods for H2 S detection are in high demand. Fluorescence-based methods thus have received great attentions in recent years. Herein we describe the design, synthesis and application of a probe for H2 S detection based on the reduction of azide to amine. This probe is highly sensitive and selective toward H2 S over biothiols and other biologically relevant species. Finally, the probe was successfully applied for H2 S fluorescent imaging in living cells.