Efficient synthesis of tetrahydronaphthalene- or isochroman-fused spirooxindoles using tandem reactions. Issue 107 (19th October 2015)

• Record Type: Journal Article
• Authors: Wang, Biao; Leng, Hai-Jun; Yang, Xue-Yuan; Han, Bo; Rao, Chao-Long; Liu, Li; Peng, Cheng; Huang, Wei
• Is Part Of: RSC advances. Volume 5:Issue 107(2015)
• Page Start: 88272
• Page End: 88276
• Publication Date: 2015-10-19
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c5ra15735h
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : The cascade reaction involving a Michael–aldol or vinylogous Henry-acetalization relay is described. We have used the cascade reaction to assemble tetrahydronaphthalene- or isochroman-fused spirooxindoles and other drug-like spirocyclic scaffolds. Abstract : The flexible and simple cascade reaction involving a Michael–aldol or vinylogous Henry-acetalization relay is described. We have used the cascade reaction to assemble functionalized tetrahydronaphthalene- or isochroman-fused spirooxindoles and other drug-like spirocyclic scaffolds. The mild reaction conditions, short reaction times, and high tolerance for various functional groups make this method attractive for constructing pharmacologically interesting architectures.