Fever after lung radiofrequency ablation: Prospective evaluation of its incidence and associated factors. Issue 11 (November 2015)

• Record Type: Journal Article
• Authors: Masaoka, Yoshihisa; Hiraki, Takao; Gobara, Hideo; Iguchi, Toshihiro; Fujiwara, Hiroyasu; Matsui, Yusuke; Toyooka, Shinichi; Soh, Junichi; Kiura, Katsuyuki; Kanazawa, Susumu
• Is Part Of: European journal of radiology. Volume 84:Issue 11(2015)
• Page Start: 2202
• Page End: 2209
• Publication Date: 2015-11
• Subjects: Lung -- Radiofrequency ablation -- Fever -- Pulmonary infiltration; Medical radiology -- Periodicals; Radiology -- Periodicals; Radiologie médicale -- Périodiques; Medical radiology; Periodicals; 616.075705
• DOI: 10.1016/j.ejrad.2015.07.009
• Languages: English
• ISSNs: 0720-048X

Abstract

Highlights: We investigated the incidence of post-lung radiofrequency ablation fever. The factors associated with the presence and grade of fever were also evaluated. The incidence of post-ablation fever was 73%. Ablated parenchymal volume and pulmonary infiltration were associated with fever. Pulmonary infiltration was associated with higher grade of fever. Abstract: Purpose: To prospectively investigate the incidence of post-lung radiofrequency (RF) ablation fever as well as its associated factors, according to the grade of fever. Materials and Methods: A total of 56 patients who underwent 67 lung RF sessions were analyzed. Post-ablation fever (≥37.0 °C) was graded according to the common toxicity criteria of adverse events v. 4.0. Fever ≥37.0 °C and <38.0 °C was defined as grade 0 fever. The 67 RF sessions were divided into two groups according to the presence of post-ablation fever, and the factors associated with fever were determined using univariate and multivariate analyses. Subsequently, the RF sessions accompanied by post-ablation fever were further divided into two groups according to the grade of fever (grade 0 vs. grade ≥1), and the factors associated with the grade of fever were determined. Results: Grade 0, 1, and 2 fever accompanied 36 (54%), 11 (16%), and 2 (3%) sessions, respectively. Post-ablation fever was significantly associated with larger ablated parenchymal volume ( P = 0.001) and development of pulmonary infiltration ( P = 0.004). Additionally, development of pulmonary infiltration ( P = 0.048) was also significantly and independently associated with higher grade of fever in the multivariate analysis. Conclusions: The incidences of grade 0, 1, and 2 post-ablation fever were 54%, 16%, and 3%, respectively. Larger ablated parenchymal volume and development of pulmonary infiltration were found to be associated with the development of post-ablation fever, with the latter being an independent factor associated with higher grade of fever.