Overcoming translational challenges – The delivery of mechanical stimuli in vivo. (December 2015)

• Record Type: Journal Article
• Authors: Markides, Hareklea; McLaren, Jane S.; El Haj, Alicia J.
• Is Part Of: International journal of biochemistry & cell biology. Volume 69(2015:Dec.)
• Page Start: 162
• Page End: 172
• Publication Date: 2015-12
• Subjects: BMP bone morphogenetic protein -- CSBD critical sized bone defect -- ECM extracellular matrix -- FGF fibroblastic growth factor -- HA hydroxyapatite -- hADMSCs human adipose derived mesenchymal stem cells -- BM-hMSCs human bone marrow derived mesenchymal stem cells -- MNP magnetic nanoparticles -- MSCs mesenchymal stem cells -- PEG polyethylene glycol -- PLGA poly(lactic-co-glycolic acid) -- PLLA poly lactic acid -- PRP platelet-rich plasma -- PTH parathyroid hormone -- RGD arginylglycylaspartic acid -- SPIONs superparamagnetic iron oxide nanoparticles -- TCP tricalcium phosphate -- TGF-β transforming growth factor – beta -- VEGF vascular endothelial growth factor; Bone -- Mechanotransduction -- Clinical translation -- Animal models -- Translational challenges -- Magnetic nanoparticles; Biochemistry -- Periodicals; Cytology -- Periodicals; Biochemistry -- Periodicals; Cell Biology -- Periodicals; Biochimie -- Périodiques; Cytologie -- Périodiques; Biochimie; Cytologie; Biochemistry; Cytology; Ressource Internet (Descripteur de forme); Périodique électronique (Descripteur de forme); Periodicals; 572.05
• DOI: 10.1016/j.biocel.2015.10.011
• Languages: English
• ISSNs: 1357-2725

Abstract

Abstract: Despite major medical advances, non-union bone fractures and skeletal defects continue to place significant burden on the patient, the clinicians and the healthcare system as a whole. Current bone substitute approaches are still limited in effectiveness and to date no adequate bone substitute material has been developed for routine clinical application. Tissue engineering presents a novel approach to tackling this clinical burden and developing an acceptable solution for the treatment of skeletal defects. Over the past three decades the field has evolved to appreciate the key biological, material and physical parameters influencing the development of a cell-based tissue engineered therapy and to create associated technologies to exploit such parameters. In recent years a number of therapies have started progressing along the pre-clinical pipeline to build a case for regulatory approval and ultimately clinical adoption. However, little emphasis has been given to the translational challenges faced when moving from "bench-to-bedside". One particular challenge lies in the delivery of functional mechanical stimuli to implanted cell populations to activate and promote osteogenic activities. This review introduces novel bio-magnetic approaches to overcoming this challenge.