Anti-inflammatory properties of Morus bombycis Koidzumi via inhibiting IFN-β signaling and NLRP3 inflammasome activation. (24th December 2015)

• Record Type: Journal Article
• Authors: Oh, Na-Hyun; Han, Ji-Won; Shim, Do-Wan; Sim, Eun-Jeong; Koppula, Sushruta; Kwak, Su-Bin; Kim, Myong-Ki; Kim, Young-Kyu; Jiang, Jun; Park, Pyo-Jam; Kang, Tae-Bong; Lee, Kwang-Ho
• Is Part Of: Journal of ethnopharmacology. Volume 176(2015)
• Page Start: 424
• Page End: 428
• Publication Date: 2015-12-24
• Subjects: Morus bombycis -- Anti-inflammation -- Inflammasome -- TRIF -- Peritonitis; Ethnopharmacology -- Periodicals; Pharmacognosy -- Periodicals; Herbs -- Periodicals; Herbs -- Periodicals; Pharmacognosy -- Periodicals; Pharmacognosie -- Périodiques; Herbes -- Périodiques; 615.1
• DOI: 10.1016/j.jep.2015.11.022
• Languages: English
• ISSNs: 0378-8741

Abstract

Abstract: Ethnopharmacological relevance: Morus bombycis Koidzumi ( M. bombycis, Moraceae) has been used in Asian countries as a traditional medicine for the treatment of hypertension, diabetes, and inflammation-related disorders. Aim of study: Although its anti-inflammatory actions have been partly documented, scientific evidence involving its molecular mechanisms related to inflammasome activation signaling pathways remains unknown. Materials and methods: Lipopolysaccharide-stimulated RAW 264.7 cells and bone marrow-derived murine macrophages were used to study the in vitro effect of methanolic extract of M. bombycis (MB) on inflammatory responses. A monosodium urate crystal (MSU)-induced peritonitis murine model was used to study the in vivo effects. Results: MB attenuated the production of nitric oxide and interleukin-6, through the regulation of the interferon-β receptor signaling pathway. MB also inhibited IL-1β secretion via attenuation of NLRP3 inflammasome activation. Furthermore, MB inhibited MSU-induced peritonitis in the in vivo murine model. Conclusions: This study provides the key molecular mechanisms involved in the anti-inflammatory effects of M. bombycis, substantiating the traditional claims of its use in the treatment of inflammation-related disorders. Graphical abstract: