Calcium signaling in membrane repair. (September 2015)

• Record Type: Journal Article
• Authors: Cheng, Xiping; Zhang, Xiaoli; Yu, Lu; Xu, Haoxing
• Is Part Of: Seminars in cell & developmental biology. Volume 45(2015)
• Page Start: 24
• Page End: 31
• Publication Date: 2015-09
• Subjects: TRPML1 -- Ca2+ -- Lysosomal exocytosis -- Calcium sensor -- Membrane repair; Cytology -- Periodicals; Developmental biology -- Periodicals; 571.6
• DOI: 10.1016/j.semcdb.2015.10.031
• Languages: English
• ISSNs: 1084-9521

Abstract

Abstract: Resealing allows cells to mend damaged membranes rapidly when plasma membrane (PM) disruptions occur. Models of PM repair mechanisms include the "lipid-patch", "endocytic removal", and "macro-vesicle shedding" models, all of which postulate a dependence on local increases in intracellular Ca 2+ at injury sites. Multiple calcium sensors, including synaptotagmin (Syt) VII, dysferlin, and apoptosis-linked gene-2 (ALG-2), are involved in PM resealing, suggesting that Ca 2+ may regulate multiple steps of the repair process. Although earlier studies focused exclusively on external Ca 2+, recent studies suggest that Ca 2+ release from intracellular stores may also be important for PM resealing. Hence, depending on injury size and the type of injury, multiple sources of Ca 2+ may be recruited to trigger and orchestrate repair processes. In this review, we discuss the mechanisms by which the resealing process is promoted by vesicular Ca 2+ channels and Ca 2+ sensors that accumulate at damage sites.